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February 17, 2026Open Access

Chromatin Remodeling Factor Arp8 Is Involved in the Regulation of Aflatoxin Biosynthesis and Fungal Pathogenicity of Aspergillus flavus

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Authors

DMDongmei MaYYYanfang YaoWLWenxin Luo

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Overview

Demonstrates that arp8 regulates aflatoxin production and fungal pathogenicity in Aspergillus flavus, indicating its critical role in infection mechanisms.

Key Points

  • The aim is to elucidate the biological role of Arp8 in A. flavus, focusing on its impact on aflatoxin biosynthesis and pathogenicity.
  • Constructed arp8 knockout and complementation strains via homologous recombination.
  • Measured conidia production and sclerotia formation post-arp8 deletion.
  • Evaluated aflatoxin B1 biosynthesis and host infection models.
  • Conducted environmental stress experiments.
  • Performed quantitative RT-PCR analysis to identify regulatory factors.
  • Deletion of arp8 resulted in a 51% reduction in conidia production and complete loss of sclerotia formation.
  • Significant impairment of aflatoxin B1 biosynthesis observed in arp8 knockout strains.
  • Arp8 was found to be essential for A. flavus colonization of crops and infecting the model organism Bombyx mori.
  • Arp8 plays a vital role in the response to various environmental stresses.

Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/6994055d4e9c9e835dfd63f2https://doi.org/10.3390/jof12020144
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The chromatin remodeling factor Arp9 modulates drug-resistance and plays a key role in aflatoxins biosynthesis under mammalian-physiological-temperature in Aspergillus flavus2026
  2. 2COMPASS subunit Bre2 regulates chromatin remodeler Arp9 to control Aspergillus flavus aflatoxin synthesis and virulence2026 · 2 citations
  3. 3Aflrpn4 Represents a Promising Target for Mitigating Aspergillus flavus Growth and Aflatoxin Contamination2026
  4. 4FphA Positively Regulates Fungal Development and AFB<sub>1</sub> Biosynthesis and Phosphorylates Ypd1 in <i>Aspergillus flavus</i>2025 · 1 citations
  5. 5The Autophagy-Related Protein ATG8 Orchestrates Asexual Development and AFB1 Biosynthesis in Aspergillus flavus2024 · 9 citations