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February 17, 2026Open Access

A Porcine-Isolated Mycobacterium bovis Strain Exhibits Hypervirulence in a Murine Pulmonary Tuberculosis Model

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Authors

MCMaría Ximena CuerdaNational Institute of Industrial TechnologyMCMaría Alejandra ColombattiNational Institute of Industrial TechnologyLBLuisa BernáUniversidad de la República de Uruguay

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Overview

Evaluates hypervirulence in a Mycobacterium bovis strain in a mouse model, suggesting novel treatment avenues.

Key Points

  • To evaluate the pathogenicity and immune response of a hypervirulent Mycobacterium bovis strain isolated from pigs.
  • Used a murine infection model to assess pathogenicity and organ colonization.
  • Compared the local strain MB894 with the highly virulent strain MB303 from wild boar.
  • Performed whole-genome sequencing to identify genetic features associated with virulence.
  • MB894 showed severe immunopathogenesis and higher organ multiplication rates compared to MB303.
  • Increased dissemination of MB894 to other organs was observed.
  • Genomic analysis revealed candidate genes associated with the hypervirulent phenotype.

Cite This Study

Cuerda et al. (2026) studied this question.

synapsesocial.com/papers/699405bb4e9c9e835dfd6973https://doi.org/10.3390/biology15040335
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