July 20, 2017CirculationOpen Access

The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus

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Why the study?

Does transcatheter heart valve deployment geometry affect the risk of leaflet thrombosis in patients undergoing TAVR?

Population

Patients with CoreValve, Evolut R, and SAPIEN 3 transcatheter aortic valve replacement enrolled in the…

Comparison

Transcatheter aortic valve replacement vs Patients without hypoattenuated leaflet thickening

Design

Cohort

Follow-up

postprocedural

Authors

PMPrem A. MidhaGeorgia Institute of Technology VRVrishank RaghavAuburn University RSRahul SharmaGeorge Washington University Hospital

Discussion

Member takes

Implication

Leaflet thrombosis was associated with greater SAPIEN 3 expansion and deeper CoreValve implantation; leaves open whether optimized deployment reduces risk.

Structured PICO

Does transcatheter heart valve deployment geometry affect the risk of leaflet thrombosis in patients undergoing TAVR?

Population

Patients with CoreValve, Evolut R, and SAPIEN 3 transcatheter aortic valve replacement enrolled in the RESOLVE study, excluding those on anticoagulation.

Intervention

Transcatheter aortic valve replacement (SAPIEN 3, CoreValve, or Evolut R)

Comparator

Patients without hypoattenuated leaflet thickening (HALT)

Outcome

Transcatheter heart valve thrombosis (evidence of hypoattenuated leaflet thickening) and thrombus volumesurrogate

Deployed transcatheter heart valve geometry, including expansion diameter and implant depth, may influence the risk of leaflet thrombosis, with supraannular deployment potentially reducing flow stasis.

Limitations

Retrospective clinical data analysis
Need for additional prospective studies

Cite This Study

Midha et al. (2017) studied this question.

synapsesocial.com/papers/6995afa058b439db10ff77b7 https://doi.org/10.1161/circulationaha.117.029479

Topics

Transcatheter aortic valve replacement TAVR in low-risk patients

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Implication

Leaflet thrombosis was associated with greater SAPIEN 3 expansion and deeper CoreValve implantation; leaves open whether optimized deployment reduces risk.

The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider