Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure
Why the study?
Does long-term therapy with oral milrinone improve morbidity and mortality in patients with severe chronic heart failure?
Population
Patients with severe chronic heart failure
Follow-up
long-term
Authors
Discussion
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Member takes
Implication
Avoid long-term oral milrinone in severe chronic HF; this RCT establishes harm and challenges inotrope strategies.
Structured PICO
Does long-term therapy with oral milrinone improve morbidity and mortality in patients with severe chronic heart failure?
P
Population
Patients with severe chronic heart failure
I
Intervention
Oral milrinone (long-term therapy)
O
Outcome
Morbidity and mortalityhard clinical
Long-term oral milrinone therapy increases morbidity and mortality in patients with severe chronic heart failure.
Cite This Study
Packer et al. (1991) studied this question.