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February 19, 2026British Journal Of NutritionOpen Access

Circulating Fatty Acids and Osteoarthritis: Evidence from Observational and Genetic Analyses

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Authors

JZJinyu ZhouXZXunying ZhaoTHTao Han

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Overview

Observational and genetic analyses identify fatty acids' association with osteoarthritis, suggesting dietary interventions.

Key Points

  • This research investigates how different types of fatty acids relate to the risk of osteoarthritis.
  • Leveraged data from the UK Biobank and large genome-wide association studies.
  • Conducted observational analyses to identify risk and protective factors among fatty acids.
  • Utilized Mendelian randomization to examine causal relationships between fatty acids and osteoarthritis.
  • Performed cross-trait meta-analysis to uncover shared genetic loci.
  • Executed enrichment analysis on detected genomic regions.
  • Saturated fatty acids (SFA) identified as a risk factor for osteoarthritis.
  • Monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) found to have protective effects against osteoarthritis.
  • Detected 68 pleiotropic loci shared between fatty acids and osteoarthritis, with nine being novel.
  • Significant local genetic signals observed in three specific genomic regions.
  • Evidence for a causal relationship between MUFA, PUFA, and osteoarthritis confirmed using Mendelian randomization.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6996a768ecb39a600b3ed071https://doi.org/10.1017/s0007114526106291
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