Unexpected 123I FP-CIT (DaT SCAN) Uptake in Palpebral Conjunctival Melanoma

A 60-year-old woman underwent evaluation for a 6-year history of Parkinsonism. One year earlier, she had been diagnosed with malignant melanoma of the left palpebral conjunctiva, which recurred despite treatment. For the assessment of Parkinson disease, 123 I FP-CIT and Tc-99m ECD SPECT were performed. Unexpectedly, intense 123 I FP-CIT uptake was observed in the left eyelid lesion, whereas 99m Tc-ECD showed no uptake. CT and MRI demonstrated a corresponding mass consistent with recurrent malignant melanoma. This first report underscores the need to recognize extrastriatal tracer uptake.