What does this research mean for the field?

Ciprofol ameliorates cerebral ischemia-reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research investigates how ciprofol protects against cerebral ischemia-reperfusion injury and its molecular mechanisms.

February 19, 2026Scientific ReportsOpen Access

Ciprofol attenuates cerebral Ischemia‒reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK

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This research investigates how ciprofol protects against cerebral ischemia-reperfusion injury and its molecular mechanisms.
Fifty male SD rats divided into groups: control, model, ciprofol, erastin, and compound C.
Cerebral ischemia induced by middle cerebral artery occlusion with reperfusion (MCAO/R).
Neurological deficits measured via modified Garcia JH scores and histopathological evaluations using Nissl staining and TTC.
Biochemical analyses of malondialdehyde, inflammatory cytokines, and ferroptosis proteins via Western blotting.
Ciprofol-treated rats showed improved modified Garcia JH scores and reduced infarct areas compared to the model group (P < 0.05).
Significant reductions in malondialdehyde, inflammatory cytokines, and ACSL4 protein expression were noted in ciprofol-treated rats (P < 0.05).
Ciprofol increased GPX4 levels and p-AMPK/T-AMPK ratios versus model group (P < 0.05).
Compared to ciprofol, erastin led to GPX4 downregulation and iron accumulation in rats.

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Implication

Experimental study demonstrates ciprofol's neuroprotective effects against CIRI in rats, suggesting therapeutic potential.

Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/6996a818ecb39a600b3ee74a https://doi.org/10.1038/s41598-026-40104-6

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Ciprofol attenuates cerebral Ischemia‒reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK

Key Points

Discussion

Implication

Cite This Study

Ciprofol attenuates cerebral Ischemia‒reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK

Key Points

Discussion

Implication

Cite This Study

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