Panak Kalpana: A Review on Its Role in Anupana and Drug Bioavailability

Panak Kalpana is a classical Ayurvedic pharmaceutical process involving the preparation of herbal decoctions, juices, and other liquid formulations. Its significance in enhancing drug bioavailability and serving as an effective Anupana (vehicle or adjuvant) has been acknowledged in Ayurvedic therapeutics. This review provides a comprehensive overview of Panak Kalpana, its classification, preparation techniques, and its role in modulating pharmacokinetics and pharmacodynamics of herbal drugs. The synergy between Anupana and active phytoconstituents can improve absorption, reduce toxicity, and optimize therapeutic outcomes. Understanding the scientific basis behind these traditional practices can aid in modern formulation development and evidence-based Ayurveda.