What question did this study set out to answer?

The study aims to identify gene expression profiles that predict pathologic complete response in triple-negative breast cancer to aid treatment decisions.

February 19, 2026Clinical Cancer Research

Abstract PS4-04-01: A 15-Gene Predictive Signature for Pathologic Complete Response in Triple-Negative Breast Cancer: Validation Across Institutional and TCGA Cohorts

View Full Paper

Ask AI

Bookmark

Authors

MHM. HouKaohsiung Medical University MPM. PanKaohsiung Medical University SMS. MOIKaohsiung Medical University

Discussion

Member takes

Implication

Identifies a gene signature predicting pathologic complete response in triple-negative breast cancer, suggesting improved treatment strategies.

Key Points

The study aims to identify gene expression profiles that predict pathologic complete response in triple-negative breast cancer to aid treatment decisions.
Tumor samples from 16 TNBC patients were collected, including 5 with pCR and 11 without.
RNA sequencing was conducted to analyze gene expression.
Differentially expressed genes were identified using DESeq2 with specific criteria.
Validation of gene expression patterns was performed with an external cohort from TCGA.
Drug-gene interaction databases were utilized to assess therapeutic relevance.
175 differentially expressed genes were identified in the KMUH cohort, including 146 upregulated and 29 downregulated in non-pCR tumors.
Fifteen genes demonstrated consistent expression in both KMUH and TCGA cohorts associated with pCR.
These genes were enriched in samples with pCR, suggesting their potential as predictive biomarkers.
Several identified genes may be targeted therapeutically, indicating their role in treatment.

Cite This Study

Hou et al. (2026) studied this question.

synapsesocial.com/papers/6996a82decb39a600b3eeac3 https://doi.org/10.1158/1557-3265.sabcs25-ps4-04-01

View Full Paper

Ask AI

Bookmark

Implication

Identifies a gene signature predicting pathologic complete response in triple-negative breast cancer, suggesting improved treatment strategies.

Abstract PS4-04-01: A 15-Gene Predictive Signature for Pathologic Complete Response in Triple-Negative Breast Cancer: Validation Across Institutional and TCGA Cohorts

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PS4-04-01: A 15-Gene Predictive Signature for Pathologic Complete Response in Triple-Negative Breast Cancer: Validation Across Institutional and TCGA Cohorts

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider