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February 19, 2026Clinical Cancer Research

Abstract PS4-03-29: N-nose as a non-invasive biomarker for predicting neoadjuvant chemotherapy response in breast cancer patients

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Authors

ANAkira NakakamiYTYoshihisa TokumaruYNY. Niwa

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Overview

This prospective study demonstrates the N-NOSE method's ability to predict chemotherapy outcomes in breast cancer, highlighting its potential as a reliable diagnostic tool.

Key Points

  • To evaluate the predictive ability of the N-NOSE method for neoadjuvant chemotherapy response in breast cancer patients.
  • Enrolled 36 breast cancer patients for neoadjuvant chemotherapy and surgery.
  • Collected urine samples at three time points: before chemotherapy, before surgery, and four weeks post-surgery.
  • Conducted chemotactic assays using C. elegans and calculated the chemotaxis index and Index Reduction Score.
  • 13 patients (36.1%) achieved pathological complete response (pCR), and 16 patients (44.4%) achieved partial response (pPR).
  • AUC for the response indicator showed variations: 0.53 for IRS1, 0.76 for IRS2, and 0.66 for IRS3, indicating IRS2 had the highest predictive ability.
  • Analysis specific to pCR revealed AUCs of 0.58 for IRS1, 0.64 for IRS2, and 0.75 for IRS3.

Cite This Study

Nakakami et al. (2026) studied this question.

synapsesocial.com/papers/6996a84cecb39a600b3eed26https://doi.org/10.1158/1557-3265.sabcs25-ps4-03-29
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 6091: Multi-cancer early cancer detection and cancer-type identification with high sensitivity non-invasive using urine: Pancreatic lung cancer early detection2024
  2. 2Urine-Based Nematode Chemotaxis Assay (N-NOSE) as a Predictor of Recurrence After Curative Surgery for Resectable Pancreatic Cancer: A Single-Center Prospective Study2025
  3. 3Abstract PO3-14-10: A single-center prospective cohort study to evaluate circulating tumor cells as a monitoring tool in women with breast cancer treated with neoadjuvant chemotherapy: final results of baseline data2024
  4. 4Abstract PS4-01-23: Transcriptomic Profiling and Immune-metabolic Prediction Model Construction for Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer Patients2026
  5. 5Abstract PO1-23-01: A novel nomogram for predicting the possibility of omitting axillary lymph node dissection after neoadjuvant chemotherapy for clinical node-positive breast cancer2024