What question did this study set out to answer?

This study aims to clarify the prognostic significance of axillary status and assess the feasibility of omitting axillary lymph node dissection in patients with isolated internal mammary lymph node metastasis.

February 19, 2026Clinical Cancer Research

Abstract PS2-03-29: Evaluating Prognosis According to Axillary Surgery in Breast Cancer Patients with Isolated Internal Mammary Lymph Node Metastasis (cN2b): A Retrospective Cohort Study

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This study aims to clarify the prognostic significance of axillary status and assess the feasibility of omitting axillary lymph node dissection in patients with isolated internal mammary lymph node metastasis.
Retrospective analysis of breast cancer patients with isolated IMLN metastasis confirmed by cytology.
Patients were stratified into groups based on axillary involvement: cN2b (isolated IMLN) and cN3b (IMLN with AXLN).
Clinicopathological characteristics and 5-year disease-free survival were compared between the two groups.
Further evaluation of oncologic outcomes based on type of axillary surgery—sentinel lymph node biopsy versus ALND—in the cN2b cohort.
125 patients were included in the analysis, with 21 in the cN2b group and 104 in the cN3b group.
5-year disease-free survival was significantly better in the cN2b group compared to cN3b (94.7% vs. 64.0%).
No locoregional failures were observed in the SLNB-only group with cN2b patients.

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Implication

Retrospective cohort study evaluates the impact of axillary surgery on outcomes in breast cancer with isolated IMLN metastasis, suggesting potential for less invasive treatment.

Cite This Study

Ishizaka et al. (2026) studied this question.

synapsesocial.com/papers/6996a869ecb39a600b3ef1e1 https://doi.org/10.1158/1557-3265.sabcs25-ps2-03-29

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Implication

Retrospective cohort study evaluates the impact of axillary surgery on outcomes in breast cancer with isolated IMLN metastasis, suggesting potential for less invasive treatment.

Abstract PS2-03-29: Evaluating Prognosis According to Axillary Surgery in Breast Cancer Patients with Isolated Internal Mammary Lymph Node Metastasis (cN2b): A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

Abstract PS2-03-29: Evaluating Prognosis According to Axillary Surgery in Breast Cancer Patients with Isolated Internal Mammary Lymph Node Metastasis (cN2b): A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

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