What question did this study set out to answer?

To evaluate the long-term oncologic outcomes of sentinel lymph node biopsy (SLNB) alone for residual axillary nodal disease following neoadjuvant chemotherapy.

February 19, 2026Clinical Cancer Research

Abstract PS2-01-15: Long-term outcomes of sentinel lymph node biopsy alone for breast cancer with residual axillary nodal disease (ypN+) following neoadjuvant chemotherapy: a systematic review and meta-analysis

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Authors

MRMariam RanaUniversity of Regina AWA. C. WeissUniversity of Rochester ALA. D. LawsUniversity of Calgary

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Implication

Meta-analysis finds SLNB alone may be safe for breast cancer patients with residual nodal disease, suggesting less surgery needed.

Key Points

To evaluate the long-term oncologic outcomes of sentinel lymph node biopsy (SLNB) alone for residual axillary nodal disease following neoadjuvant chemotherapy.
Conducted a systematic review and meta-analysis following PRISMA guidelines.
Searched Medline, Embase, and Cochrane Central Registry for relevant studies.
Included studies that reported outcomes like axillary recurrence, locoregional recurrence, distant recurrence, disease-free survival, or overall survival.
Used a random effects meta-analysis to calculate risk ratios for SLNB vs. ALND across studies.
Included 14 studies with a total of 9,518 patients.
No significant differences in axillary recurrence or overall mortality between SLNB and ALND.
Lower risk of distant recurrence observed for SLNB alone (RR 0.75, 95% CI: 0.60-0.95).
Axillary recurrence rates were low across studies, mostly distant recurrences.

Cite This Study

Rana et al. (2026) studied this question.

synapsesocial.com/papers/6996a869ecb39a600b3ef0cf https://doi.org/10.1158/1557-3265.sabcs25-ps2-01-15

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Abstract PS2-01-15: Long-term outcomes of sentinel lymph node biopsy alone for breast cancer with residual axillary nodal disease (ypN+) following neoadjuvant chemotherapy: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract PS2-01-15: Long-term outcomes of sentinel lymph node biopsy alone for breast cancer with residual axillary nodal disease (ypN+) following neoadjuvant chemotherapy: a systematic review and meta-analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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