What does this research mean for the field?

Axillary radiotherapy is non-inferior to axillary lymph node dissection in patients with positive sentinel lymph node biopsy, with a 5-year axillary recurrence rate of 2.67%. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To evaluate axillary recurrence rates in breast cancer patients treated with radiotherapy versus axillary lymph node dissection after positive sentinel lymph node biopsy.

February 19, 2026Clinical Cancer Research

Abstract PS2-03-03: Retrospective analysis of axillary recurrence in patients with breast cancer receiving radiotherapy to the axillary after positive sentinel lymph node biopsy

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Authors

CGC. GavisiddappaUniversity Hospitals of Morecambe Bay NHS Foundation Trust RPRishikesh ParmeshwarUniversity Hospitals of Morecambe Bay NHS Foundation Trust PMPenelope McManusUniversity Hospitals of Morecambe Bay NHS Foundation Trust

Discussion

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Implication

Retrospective analysis finds axillary radiotherapy effectively manages recurrence in breast cancer patients, indicating a safer option.

Key Points

To evaluate axillary recurrence rates in breast cancer patients treated with radiotherapy versus axillary lymph node dissection after positive sentinel lymph node biopsy.
Retrospective analysis of 186 patients with positive sentinel lymph node biopsy from June 2015 to June 2022.
Patients receiving axillary radiotherapy were compared to those undergoing axillary lymph node dissection for recurrence rates and morbidity.
Follow-up period averaged 5.58 years to assess long-term outcomes.
Axillary recurrence was observed in 2.67% of patients receiving radiotherapy.
Lymphedema occurred in 0.89% of patients.
Overall mortality was lower in the current study compared to AMAROS trial findings, with 7.84% versus 10.3% for breast cancer-related deaths.

Cite This Study

Gavisiddappa et al. (2026) studied this question.

synapsesocial.com/papers/6996a85cecb39a600b3eef0c https://doi.org/10.1158/1557-3265.sabcs25-ps2-03-03

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Abstract PS2-03-03: Retrospective analysis of axillary recurrence in patients with breast cancer receiving radiotherapy to the axillary after positive sentinel lymph node biopsy

Discussion

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Implication

Key Points

Cite This Study

Abstract PS2-03-03: Retrospective analysis of axillary recurrence in patients with breast cancer receiving radiotherapy to the axillary after positive sentinel lymph node biopsy

Discussion

Member takes

Implication

Key Points

Cite This Study

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