Oculogyric Crisis During Chronic Aripiprazole Therapy: A Diagnostic Challenge in the Emergency Department

Koji Tokioka; Tsuyoshi Nojima; Ippei Matsuo; Kohei Tsukahara; Atsunori Nakao

doi:10.1002/ccr3.72067

February 1, 2026Clinical Case ReportsOpen Access

Oculogyric Crisis During Chronic Aripiprazole Therapy: A Diagnostic Challenge in the Emergency Department

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Key Points

The aim is to investigate the occurrence of oculogyric crisis during stable aripiprazole therapy and highlight the diagnostic challenges it presents.
Discussion of clinical cases involving chronic aripiprazole therapy
Analysis of neurologic examinations for symptoms
Review of medication histories to identify drug-induced conditions.
Oculogyric crisis can manifest without dose adjustment in aripiprazole users.
Identifying drug-induced dystonia is crucial for accurate diagnosis and avoiding unnecessary tests.

Implication

Emergency department observations reveal oculogyric crisis in patients on aripiprazole, indicating diagnostic considerations.

Abstract

Oculogyric crisis can occur even during chronic, stable aripiprazole therapy without recent dose escalation. In patients with acute upward eye deviation and an otherwise normal neurologic examination, medication review is key to recognizing drug‐induced dystonia and avoiding unnecessary neurologic workup.

Discussion

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Cite This Study

Tokioka et al. (2026) studied this question.

synapsesocial.com/papers/6996a869ecb39a600b3ef27c https://doi.org/10.1002/ccr3.72067

View Full Paper

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Oculogyric Crisis During Chronic Aripiprazole Therapy: A Diagnostic Challenge in the Emergency Department

Key Points

Implication

Abstract

Discussion

Cite This Study

Oculogyric Crisis During Chronic Aripiprazole Therapy: A Diagnostic Challenge in the Emergency Department

Key Points

Implication

Abstract

Discussion

Cite This Study

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