What does this research mean for the field?

ESR1-low cells in untreated ER+ tumors represent a critical point in the development of endocrine therapy resistance, characterized by specific kinase signatures. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To explore the role of ESR1-low cells in the development of endocrine therapy resistance in ER+ breast tumors.

February 19, 2026Clinical Cancer Research

Abstract PS2-11-04: Transcriptional Plasticity in Early Evolving Endocrine Therapy Resistance

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Authors

YAY. N. AgrawalUniversity of North Carolina at Chapel Hill SHSantiago HaaseUniversity of North Carolina at Chapel Hill AWA. A. WhitmanUniversity of North Carolina at Chapel Hill

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Implication

Examines how low estrogen receptor cells may lead to tamoxifen resistance in breast cancer, suggesting new treatment strategies.

Key Points

To explore the role of ESR1-low cells in the development of endocrine therapy resistance in ER+ breast tumors.
Conducted single-cell RNA expression and chromatin accessibility analysis on patient-derived xenografts.
Treated models with tamoxifen or control and analyzed cell clusters using gene set enrichment analysis.
Performed trajectory analysis to understand treatment-resistant cell populations.
Found that ESR1 expression inversely correlated with several kinase activities in untreated tumors.
Identified that tamoxifen resistance arises from an untreated ESR1-low cell population.
Observed specific kinase signatures in ESR1-low cells that could indicate treatment pathways.

Cite This Study

Agrawal et al. (2026) studied this question.

synapsesocial.com/papers/6996a879ecb39a600b3ef36b https://doi.org/10.1158/1557-3265.sabcs25-ps2-11-04

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Abstract PS2-11-04: Transcriptional Plasticity in Early Evolving Endocrine Therapy Resistance

Discussion

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Implication

Key Points

Cite This Study

Abstract PS2-11-04: Transcriptional Plasticity in Early Evolving Endocrine Therapy Resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

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