What question did this study set out to answer?

The aim is to identify shared and distinct molecular signatures associated with endocrine therapy resistance in ER+ breast cancer using tumor transcriptomic data.

May 29, 2026Journal of Clinical Oncology

Shared and distinct molecular signatures of resistance to different endocrine therapies (Alliance A011106).

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Authors

MAMeenakshi AnuragBaylor College of Medicine YDYongchao DouBaylor College of Medicine JHJeremy HoogWashington University in St. Louis

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Implication

Randomized trial identifies molecular predictors of early endocrine therapy resistance in ER+ breast cancer, suggesting new treatment approaches.

Key Points

The aim is to identify shared and distinct molecular signatures associated with endocrine therapy resistance in ER+ breast cancer using tumor transcriptomic data.
Analyzed baseline RNA data from the ALTERNATE and ACOSOG Z1031B trials.
Identified differentially expressed genes and pathways linked to endocrine therapy resistance using statistical analysis.
Developed a Pan-Endocrine Therapy Signature integrating data across trials.
ETR rate was 26% in the ALTERNATE RNA-seq cohort (n=733).
Top ETR predictors included MYBL2, AURKB, and EME1 for Arm A, and IL4I1, TNFAIP6, ANLN for Arm AF.
The Pan-Endocrine Therapy Signature showed strong correlation with established signatures, indicating potential for patient stratification.

Cite This Study

Anurag et al. (2026) studied this question.

synapsesocial.com/papers/6a192ea9fab5b468c4417dec https://doi.org/10.1200/jco.2026.44.16_suppl.566

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Implication

Randomized trial identifies molecular predictors of early endocrine therapy resistance in ER+ breast cancer, suggesting new treatment approaches.

Shared and distinct molecular signatures of resistance to different endocrine therapies (Alliance A011106).

Discussion

Member takes

Implication

Key Points

Cite This Study

Shared and distinct molecular signatures of resistance to different endocrine therapies (Alliance A011106).

Discussion

Member takes

Implication

Key Points

Cite This Study

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