Key result
Each 10 μg/m3 PM2.5 increase linked to ~47% higher mortality risk in breast cancer patients.
Why the study?
Evidence on the role of ambient PM2.5 in breast cancer prognosis remains limited, with few studies evaluating its impact on progression-free survival and overall survival.
Does long-term PM2.5 exposure worsen progression-free and overall survival in breast cancer patients?
Population
18,553 breast cancer patients (2000-2019) across more than 40 medical centers in China
Comparison
Long-term ambient PM2.5 exposure levels
Design
Multicenter prospective cohort study
Authors
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PM2.5 exposure was associated with worse breast cancer survival; hypothesis-generating and leaves open whether mitigation improves outcomes.
Does long-term PM2.5 exposure worsen progression-free and overall survival in breast cancer patients?
Long-term PM2.5 exposure is independently associated with worse progression-free and overall survival in breast cancer patients, particularly in HER2-positive and triple-negative subtypes.
Zhang et al. (2026) studied this question. Each 10 μg/m3 increase in PM2.5 was associated with 28% higher progression-free survival hazard and 47% higher overall survival hazard in breast cancer patients.
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