What question did this study set out to answer?

This research aimed to identify genomic biomarkers associated with the efficacy of neoadjuvant therapy in a cohort of Chinese breast cancer patients.

February 19, 2026Clinical Cancer Research

Abstract PS4-05-07: Integrated Genomic Profiling Identifies Predictive Biomarkers for Neoadjuvant Therapy Response in Chinese Breast Cancers

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Authors

XYX. YingFudan University Shanghai Cancer Center KZK. ZhangFudan University Shanghai Cancer Center XZX. ZhuFudan University Shanghai Cancer Center

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Implication

Large-scale analysis identifies genomic biomarkers predicting neoadjuvant therapy response in Chinese breast cancer, suggesting personalized treatment strategies.

Key Points

This research aimed to identify genomic biomarkers associated with the efficacy of neoadjuvant therapy in a cohort of Chinese breast cancer patients.
Analyzed data from a cohort of 1,161 primary breast cancer patients.
Utilized FUSCC-BC targeted panel for comprehensive genomic profiling of 1,145 patients.
Developed machine learning models for predicting neoadjuvant therapy response based on genomic profiles and clinicopathological variables.
Identified subtype-specific genomic biomarkers related to varying rates of pathological complete response (pCR).
Found PIK3CA mutations and PI3K pathway activation as common resistance mechanisms in certain breast cancer subtypes.
Achieved AUC values of 0.82 in the training set and 0.81 in the test set for prediction of neoadjuvant therapy response.

Cite This Study

Ying et al. (2026) studied this question.

synapsesocial.com/papers/6996a8a9ecb39a600b3ef902 https://doi.org/10.1158/1557-3265.sabcs25-ps4-05-07

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Implication

Large-scale analysis identifies genomic biomarkers predicting neoadjuvant therapy response in Chinese breast cancer, suggesting personalized treatment strategies.

Abstract PS4-05-07: Integrated Genomic Profiling Identifies Predictive Biomarkers for Neoadjuvant Therapy Response in Chinese Breast Cancers

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Implication

Key Points

Cite This Study

Abstract PS4-05-07: Integrated Genomic Profiling Identifies Predictive Biomarkers for Neoadjuvant Therapy Response in Chinese Breast Cancers

Discussion

Member takes

Implication

Key Points

Cite This Study

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