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February 19, 2026Journal of Turkish Society of Obstetric and GynecologyOpen Access

Intrauterine infusion and sub-endometrial injection of autologous platelet-rich plasma for thin endometrium: A systematic review and single-arm meta-analysis

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Authors

ZTZhichen TangShanghai Jiao Tong UniversityQWQingxin WuSichuan UniversityMLMaoquan LiChengdu Medical College

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Implication

A systematic review evaluates PRP efficacy in improving endometrial thickness and pregnancy rates in women undergoing FET cycles, suggesting potential benefits.

Key Points

  • The aim is to evaluate the efficacy and safety of autologous platelet-rich plasma (PRP) for improving endometrial thickness and pregnancy outcomes in women with thin endometrium.
  • Systematic review of existing literature on PRP treatment for thin endometrium during FET cycles.
  • Comprehensive search in databases like PubMed and Cochrane Library.
  • Assessment of methodological quality using the Methodological Index for Non-Randomized Studies.
  • Meta-analysis calculating mean differences in endometrial thickness and proportions for pregnancy outcomes.
  • PRP significantly increased endometrial thickness by 1.61 mm (95% CI: 1.21-2.01, p<0.05).
  • The overall clinical pregnancy rate after PRP treatment was 41.5% (95% CI: 29.6-53.9%).
  • Ongoing pregnancy rate was 27.3% (95% CI: 19.7-35.0%), with an implantation rate of 22.9% (95% CI: 8.5-37.2%) and miscarriage rate of 5.3% (95% CI: 2.3-8.2%).
  • Heterogeneity observed in results attributed to differences in study design and PRP administration route.

Cite This Study

Tang et al. (2026) studied this question.

synapsesocial.com/papers/6996a957ecb39a600b3f04b5https://doi.org/10.4274/tjod.galenos.2026.29932
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subendometrial platelet-rich plasma injection for refractory thin endometrium: a prospective pilot study2026
  2. 2Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles2024 · 13 citations
  3. 3P-294 Intrauterine infusion of autologous platelet-rich plasma(PRP) for patients with refractory thin endometrium in euploid frozen embryo transfer cycles improve pregnancy outcomes2024
  4. 4Autologous platelet-rich plasma as a potential new approach in the endometrial response during in vitro fertilization cycle: A pilot study2024 · 1 citations
  5. 5Effect of Intrauterine Autologous Platelet-Rich Plasma Instillation in Infertile Women With Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial2025 · 1 citations