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February 20, 2026Биологические мембраны / Membrane and Cell Biology0 citations

Effects of Pregnancy-Specific β1-Glycoprotein on MDSC and Cytokine Profile

The Effect of Pregnancy-Specific β1-Glycoprotein on PD-L1 and CD73 Expression by Myeloid-Derived Suppressor Cells and Their Cytokine Profile

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Authors

KSK.Yu. Shardina

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Overview

Investigates how pregnancy-specific β1-glycoprotein affects myeloid-derived suppressor cells, suggesting new strategies for immune modulation.

Key Points

  • The study aims to assess the impact of pregnancy-specific β1-glycoprotein on the function and cytokine profile of myeloid-derived suppressor cells.
  • Isolated CD11b+ cells from peripheral blood using immunomagnetic separation.
  • Differentiated these cells into myeloid-derived suppressor cells with GM-CSF, IL-1β, and LPS.
  • Applied various concentrations of native and recombinant pregnancy-specific β1-glycoprotein.
  • Conducted flow cytometry for PD-L1 and CD73 expression and measured inducible nitric oxide synthase levels.
  • Analyzed cytokine profiles using multiplex assays.
  • Recombinant PSG at 1 μg/mL significantly increased PD-L1 expression on MDSCs.
  • At 10 μg/mL, recombinant PSG elevated CD73 levels on MDSCs.
  • Native PSG showed no significant effect on PD-L1 or CD73 expression.
  • Recombinant PSG reduced MIP-1β levels without affecting other cytokines.

Cite This Study

K.Yu. Shardina (2025) studied this question.

synapsesocial.com/papers/6997fa03ad1d9b11b3452f3ehttps://doi.org/10.7868/s3034521925050073
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