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May 22, 2026Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology0 citations

Impact of Pregnancy Specific Glycoprotein on MDSC and Cytokine Profile

The Effect of Pregnancy Specific Glycoprotein on the Presence of PD-L1 and CD73 Membrane Molecules on Myeloid-Derived Suppressor Cells and Their Cytokine Profile

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Authors

KSK. Yu. ShardinaVTV. P. TimganovaDUD. I. Usanina

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Overview

Randomized trial investigates how pregnancy specific glycoprotein affects immune cell molecules in healthy donors, suggesting therapeutic applications.

Key Points

  • This study aims to explore the effects of pregnancy specific glycoprotein on myeloid-derived suppressor cells and their associated cytokine profiles.
  • Peripheral blood-derived CD11b+ cells were isolated and differentiated into MDSC using GM-CSF, IL-1β, and lipopolysaccharide.
  • Cell phenotyping utilized flow cytometry to assess PD-L1 and CD73, and multiplex analysis was conducted for cytokine profiling.
  • Physiological concentrations of native and recombinant PSG were tested for their effects on MDSC activity.
  • Recombinant PSG at 1 μg/mL significantly increased PD-L1 density on MDSC (P<0.05).
  • At 10 μg/mL, recombinant PSG elevated CD73 levels while native PSG had no significant effect.
  • Recombinant PSG (10 μg/mL) reduced MIP-1β without affecting other cytokines.

Cite This Study

Shardina et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff362d674f7c03778c0c2https://doi.org/10.1134/s1990747826700054
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