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February 20, 2026BMJ OpenOpen Access

Cytometry-based blood immune cell markers associated with clinical outcomes in systemic sclerosis: protocol for a systematic review

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Authors

MSMarion SouffezCentre Hospitalier Universitaire de RennesEDErwan DumontetInsermVLValérie LecureurInserm

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Implication

This systematic review identifies immune markers in blood linked to clinical outcomes in systemic sclerosis, suggesting new predictive tools.

Key Points

  • The review aims to identify cytometry-based blood immune markers associated with clinical outcomes in systemic sclerosis.
  • Conduct a comprehensive search on PubMed, Web of Science, and Cochrane Library.
  • Include studies on flow or mass cytometry for blood cell phenotyping in adults with systemic sclerosis.
  • Compare immune markers against healthy controls and other autoimmune diseases.
  • The primary outcome will investigate the association with the diffuse cutaneous subtype.
  • Secondary outcomes include overall survival, organ involvement, and treatment response.

Cite This Study

Souffez et al. (2026) studied this question.

synapsesocial.com/papers/6997fa12ad1d9b11b3452f86https://doi.org/10.1136/bmjopen-2025-115864
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 12013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative2013 · 3,455 citations
  2. 2Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement2015 · 27,163 citations
  3. 3Alterations in peripheral T‐ and B‐cell subsets in patients with systemic sclerosis2024 · 7 citations
  4. 4Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system2024 · 13 citations
  5. 5The PRISMA 2020 statement: an updated guideline for reporting systematic reviews2021 · 107,295 citations