Unraveling the enigma of eosinophilic gastroenteritis: a rare case of multisystem involvement in an elderly patient

Eosinophilic gastroenteritis (EG), the most common form of eosinophilic gastrointestinal disease, primarily affects the stomach and small intestine. This retrospective case report, following CARE guidelines, analyzed clinical data and imaging. A 77-year-old male presented with substernal chest pain, weakness, appetite loss, and weight loss. CBC showed leukocytosis with marked eosinophilia. Abdominal CT revealed thickened jejunal loops. Biopsies confirmed eosinophilic infiltration in the duodenum and ileum, diagnosing EG. The patient was treated with prednisone, leading to significant improvement. This case highlights the importance of recognizing EG in patients with unexplained GI symptoms and eosinophilia for timely diagnosis and effective management.