Findings reveal sensory neurons drive ECM remodeling and immune exclusion in TNBC, highlighting therapeutic vulnerabilities.
The tumor microenvironment drives cancer progression, yet neural contributions remain underexplored. Zhang et al. unravel a signaling circuit involving cancer cells, sensory neurons, and cancer-associated fibroblasts that promotes desmoplasia and excludes cytotoxic T cells, positioning the neuron-fibroblast axis as a therapeutic vulnerability and potential predictor of immunotherapy response.
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Barki et al. (2026) studied this question.
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