What question did this study set out to answer?

To investigate the binding characteristics and differences of non-neutralizing antibodies targeting transferrin receptor 1.

February 21, 2026Biophysical Journal

BPS2026 – Study of non-neutralizing anti-transferrin receptor 1 antibodies

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Authors

AMAldo J. Munoz CCChantal K De La CruzUniversity of California, Irvine DSDonovan Southall

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Implication

Research demonstrates binding differences of non-neutralizing antibodies to transferrin receptor 1 in vitro, suggesting implications for pathogen inhibition.

Key Points

To investigate the binding characteristics and differences of non-neutralizing antibodies targeting transferrin receptor 1.
Assayed antibodies for binding to transferrin receptor 1 at neutral and low pH
Evaluated specificity using animal constructs of the apical domain
Assessed the ability to prevent binding of NWM pseudoviruses
Antibodies showed differing affinity for transferrin receptor 1
Identified pH dependencies and species specificity
Inhibited JUNV/MACV pseudovirus internalization via ELISA

Cite This Study

Munoz et al. (2026) studied this question.

synapsesocial.com/papers/69990de85b97ab4c14ac2870 https://doi.org/10.1016/j.bpj.2025.11.420

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Implication

Research demonstrates binding differences of non-neutralizing antibodies to transferrin receptor 1 in vitro, suggesting implications for pathogen inhibition.

BPS2026 – Study of non-neutralizing anti-transferrin receptor 1 antibodies

Discussion

Member takes

Implication

Key Points

Cite This Study

BPS2026 – Study of non-neutralizing anti-transferrin receptor 1 antibodies

Discussion

Member takes

Implication

Key Points

Cite This Study

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