What does this research mean for the field?

Prenatal lead exposure during the second trimester is associated with cognitive function in later adulthood, particularly among females. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the impact of prenatal and early postnatal lead exposure on cognitive function in later adulthood.

February 21, 2026Neurology1 citations

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Prenatal and Early Postnatal Lead Exposure and Later Adulthood Cognitive Function in the St. Louis Baby Tooth–Later Life Health Study

RHRuby HickmanHarvard University JLJoyce J.Y. Lin KMKaleigh McAlaineHarvard University

Key Points

To investigate the impact of prenatal and early postnatal lead exposure on cognitive function in later adulthood.
Analyzed data from the St. Louis Baby Tooth – Later Life Health Study.
Focused on lead exposure during pregnancy and early infancy.
Conducted coadjusted analyses to assess cognitive outcomes by exposure timing.
Statistical significance found for second trimester lead exposure among females.
Evidence suggests the second trimester is particularly relevant for cognitive function.

Abstract

We found suggestive evidence for associations between early lead exposures and later adulthood cognitive function, although these only reached statistical significance for second trimester lead exposure among females. A coadjusted analysis suggested the second trimester may be most relevant for later cognitive function.

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Prenatal and Early Postnatal Lead Exposure and Later Adulthood Cognitive Function in the St. Louis Baby Tooth–Later Life Health Study

Key Points

Abstract

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