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February 21, 2026CureusOpen Access

Three Cases of Resection of Alpha-Fetoprotein-Positive High-Grade Fetal Adenocarcinoma of the Lung From a Single Institution

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Authors

YNYusuke NabeHMHiroshi MizuuchiMIMasaaki Inoue

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Overview

Case report reveals poor prognosis in alpha-fetoprotein-positive lung adenocarcinoma, suggesting targeted therapies.

Key Points

  • Examining the clinical outcomes and biomarkers in cases of fetal lung adenocarcinoma resection.
  • Analysis of three cases with varying alpha-fetoprotein expression.
  • Immunohistochemical analysis of tumor tissues for AFP and PD-L1 levels.
  • Literature review on embryonal lung adenocarcinoma prognosis.
  • Case 1 had low AFP post-re-staining, Case 2 showed sparse AFP positivity, and Case 3 was intensely positive.
  • Case 3 exhibited elevated serum AFP levels, while only Case 2 was weakly positive for PD-L1.
  • Patient 1's >50-month survival was linked to early detection and complete resection; Cases 2 and 3 showed poor prognosis.

Cite This Study

Nabe et al. (2026) studied this question.

synapsesocial.com/papers/69994aab873532290d01f050https://doi.org/10.7759/cureus.103792
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  5. 5Benign persistent elevation of alphafoetoprotein (AFP) after curative treatment for germ-cell tumors.2026