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May 20, 2026American Journal of Respiratory and Critical Care Medicine

B80-5-26 Low Grade Foetal Adenocarcinoma of the Lung in an Adult Woman: A Rare Variant of Pulmonary Adenocarcinoma

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Authors

JAJ AL-ForiOxford University Hospitals NHS TrustAMA J MooreOxford University Hospitals NHS TrustATA TalwarOxford University Hospitals NHS Trust

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Implication

Randomized trial demonstrates favorable prognosis in adult women with low-grade foetal adenocarcinoma, highlighting its importance for surgical planning.

Key Points

  • The aim is to describe the presentation and management of low-grade foetal adenocarcinoma in an adult woman.
  • Case study of a 44-year-old woman presenting with a left lower lobe mass
  • Surgical intervention included left pneumonectomy with histological analysis
  • Immunohistochemistry confirmed diagnosis and molecular testing ruled out common mutations
  • Histological examination confirmed low-grade foetal adenocarcinoma with a 5-year survival rate exceeding 75%
  • Immunohistochemistry showed diffuse nuclear and cytoplasmic β-catenin expression
  • Negative results for ALK and ROS1 rearrangements, indicating a distinct tumor profile

Cite This Study

AL-Fori et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5098f03e14405aa9c8b2https://doi.org/10.1093/ajrccm/aamag162.3840
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[High-grade Fetal Adenocarcinoma of the Lung with Scalp Metastasis: A Case Report].2024 · 1 citations
  2. 2A component of high‐grade fetal lung adenocarcinoma diagnosed as the cause of lymph node metastasis2024 · 2 citations
  3. 3Low‐Grade Fetal Adenocarcinoma of the Lung on 18 F ‐ FDG PET / CT2025
  4. 4Intraoperative cytology of low-grade fetal adenocarcinoma: Critical morphological features for distinction from carcinoid tumor2025
  5. 5Early-Stage High-Grade Fetal Lung Adenocarcinoma With KRAS Mutation: A Rare Presentation and Literature Review2026