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July 30, 2026International Journal of Surgical Pathology

Early-Stage High-Grade Fetal Lung Adenocarcinoma With KRAS Mutation: A Rare Presentation and Literature Review

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Authors

BPBaoxiang PeiZHZhiliang HuFPFen Pan

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Overview

Case report highlights early-stage high-grade fetal lung adenocarcinoma in a rare patient, suggesting surgical resection as standard treatment.

Key Points

  • This paper aims to present a rare case of early-stage high-grade fetal lung adenocarcinoma and its treatment outcomes.
  • Case report of a non-smoking elderly woman who underwent single-port thoracoscopic left lower lung wedge resection.
  • Intraoperative frozen pathology was performed, followed by lobectomy and mediastinal lymphadenectomy based on findings.
  • Postoperative pathological evaluation confirmed diagnosis and staging of pT1bN0 IA2.
  • The patient had a 17-month follow-up period and remained disease-free without adjuvant therapy.
  • Pathological examination confirmed the presence of KRAS mutation in the identified tumor.
  • Standard treatment of surgical resection was highlighted as the effective management for this rare cancer.

Cite This Study

Pei et al. (2026) studied this question.

synapsesocial.com/papers/6a6af50460e2b924d3ea09aehttps://doi.org/10.1177/10668969261463674
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1B80-5-26 Low Grade Foetal Adenocarcinoma of the Lung in an Adult Woman: A Rare Variant of Pulmonary Adenocarcinoma2026
  2. 2Uniportal video-assisted thoracoscopic segmentectomy for fetal adenocarcinoma lung cancer with severe pulmonary emphysema: a case report2024
  3. 3[High-grade Fetal Adenocarcinoma of the Lung with Scalp Metastasis: A Case Report].2024 · 1 citations
  4. 4D110-19 Hepatoid Adenocarcinoma of the Lung: A Rare and Deadly Diagnosis2026
  5. 5Dual EGFR L858R and KRAS G12A Mutations in Lung Adenocarcinoma: A Rare Case Report and Literature Review2025