What question did this study set out to answer?

The aim is to highlight an atypical presentation of POEMS syndrome in a patient with a plasma cell disorder, emphasizing diagnosis and management challenges.

February 21, 2026CureusOpen Access

Atypical Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes (POEMS) Syndrome

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Authors

MBM BisharaUPMC Central Pa AHAnna HomeniukUPMC Central Pa APAayush PatelDrexel University

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Implication

Case report reveals atypical POEMS syndrome diagnosis in an older female with plasma cell disorder, suggesting the need for broad differential considerations.

Key Points

The aim is to highlight an atypical presentation of POEMS syndrome in a patient with a plasma cell disorder, emphasizing diagnosis and management challenges.
Case report of an 82-year-old female with thrombocytosis and prior stroke history.
Clinical examination and workup including hematological tests and bone marrow biopsy.
Electromyography (EMG) testing to assess polyneuropathy status.
Evaluation of serum vascular endothelial growth factor (VEGF) levels.
Patient presented with a kappa-restricted monoclonal gammopathy and elevated serum free kappa light chain.
Bone marrow biopsy revealed 20% to 30% plasma cell infiltration consistent with smoldering multiple myeloma (SMM).
EMG testing indicated subclinical polyneuropathy, supporting atypical POEMS diagnosis.
Markedly elevated VEGF levels were noted, reinforcing the diagnosis of atypical POEMS.

Cite This Study

Bishara et al. (2026) studied this question.

synapsesocial.com/papers/69994aab873532290d01f14b https://doi.org/10.7759/cureus.103791

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Implication

Case report reveals atypical POEMS syndrome diagnosis in an older female with plasma cell disorder, suggesting the need for broad differential considerations.

Atypical Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes (POEMS) Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Atypical Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Protein, and Skin Changes (POEMS) Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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