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September 19, 2025Case Reports in HematologyOpen Access

POEMS Syndrome Without a Detectable Monoclonal Peak: The Critical Role of VEGF and Bone Marrow Biopsy in Diagnosis

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Case study reveals elevated VEGF and bone marrow biopsy aided POEMS syndrome diagnosis, indicating importance of awareness.

Diagnosis of POEMS syndrome was confirmed through elevated VEGF levels and bone marrow biopsy, despite no monoclonal peak seen.
The patient experienced progressive symptoms initially misdiagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP), complicating her diagnosis.
Elevated VEGF levels of 11.245 pg/mL were noted, showing its critical role in the diagnosis of POEMS syndrome.
Early recognition and treatment are essential to prevent complications associated with POEMS syndrome's prothrombotic nature.

Pecorin et al. (2025) studied this question.

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