Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 21, 2026ACS Applied Materials & Interfaces

Reprogramming the In Vivo Fate of Nanoassemblies: Morphology Regulation to Rod-Like Nanostructures to Enhance Antitumor Efficacy

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJing ZhangTLTian LiuYLYaqiao Li

Discussion

Loading...

Member takes

Overview

Novel strategies improve tumor targeting and circulation of drug delivery systems, suggesting new avenues for cancer therapy.

Key Points

  • This study aims to develop a method for controlling the morphology of nanoparticles to enhance their effectiveness in cancer treatment.
  • Utilized prodrug nanoassemblies as a model for morphology regulation.
  • Employed an ultrasound-assisted one-step nanoprecipitation method.
  • Transformed spherical nanostructures into uniform rod-like nanostructures.
  • Evaluated the biological impact of these transformations on drug efficacy.
  • Rod-like nanostructures (AR5) showed reduced macrophage uptake and prolonged blood circulation.
  • Enhanced tumor accumulation compared to spherical nanoparticles.
  • Rod-like nanostructures exhibited superior antitumor efficacy.
  • Optimal aspect ratio was identified for effective tumor cell uptake.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69994ba9873532290d01fc00https://doi.org/10.1021/acsami.5c25772
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flexible Morphological Regulation of Photothermal Nanodrugs: Understanding the Relationship between the Structure, Photothermal Effect, and Tumoral Biodistribution2025 · 11 citations
  2. 2A Topology-to-Therapy Map for Prodrug Nanoassemblies2026
  3. 3Programmable Nanostructure Assembly of a Paclitaxel Derivative Enables Tunable Anticancer Therapy via Hydrogen Bond Engineering2025
  4. 4Structural Topology of Prodrug Nanoassembly: First Steps Toward Nano‐QSAR2026
  5. 5Supramolecularly-Cross-Linked Nanogel Assemblies for On-Demand, Ultrasound-Triggered Chemotherapy2024 · 4 citations