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September 10, 2025ACS NanoOpen Access

Programmable Nanostructure Assembly of a Paclitaxel Derivative Enables Tunable Anticancer Therapy via Hydrogen Bond Engineering

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Authors

GFGuobing FengHTHui TangSXShuyi Xie

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Overview

This research demonstrates hydrogen bonding's role in programming drug morphology, optimizing therapeutic efficacy for cancer treatments.

Key Points

  • Nanostructuring a paclitaxel derivative improved its antitumor efficacy and pharmacokinetics in cancer models.
  • PTP@PEG nanoparticles enhanced systemic circulation and reduced renal accumulation, crucial for effective drug delivery.
  • Using hydrogen bonding to tune drug assembly morphology offers a versatile platform for treating multiple cancer types.
  • Transforming drug morphology with simple excipients may revitalize previously limited drugs, expanding their applications.

Cite This Study

Feng et al. (2025) studied this question.

synapsesocial.com/papers/68c1d23054b1d3bfb60f7c6bhttps://doi.org/10.1021/acsnano.5c10267
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hydrophobically Modified Paclitaxel Prodrug Enables Ultrahigh Drug Loading Driven by Polarity Redistribution2025
  2. 2Enhanced Anti-Tumor Efficacy of Paclitaxel Nanoparticles via Supramolecular Self-Assembly with Pterostilbene2025 · 1 citations
  3. 3Hyaluronic Acid‐Decorated Hollow Nanocapsules for Enhanced Tumor‐Targeted Chemotherapy2026
  4. 4Reprogramming the In Vivo Fate of Nanoassemblies: Morphology Regulation to Rod-Like Nanostructures to Enhance Antitumor Efficacy2026 · 1 citations
  5. 5Phospholipid‐Drug Conjugates Self‐Organized into Well‐Defined Supramolecular Nanotubes for Efficient Drug Delivery2025