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Phospholipid‐Drug Conjugates Self‐Organized into Well‐Defined Supramolecular Nanotubes for Efficient Drug Delivery

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This research demonstrates the formation of supramolecular nanotubes from phospholipid drug conjugates, implying enhanced drug delivery efficiency.

PCC nanotubes exhibit high drug-loading efficiencies ranging from 43.9% to 52.3%, significantly boosting drug delivery.
The precise modulation of hydrophobic characteristics plays a critical role in controlling nanotube length and polydispersity.
PCC nanotubes show tumor-selective cytotoxicity with 20- to 50-fold greater potency against tumor cells than normal cells.
Nanotubes formed are of intermediate length (0.3–0.5 µm), providing advantages like prolonged circulation times over conventional liposomes.

Gao et al. (2025) studied this question.

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View Full Paper

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Authors

This research demonstrates the formation of supramolecular nanotubes from phospholipid drug conjugates, implying enhanced drug delivery efficiency.

PCC nanotubes exhibit high drug-loading efficiencies ranging from 43.9% to 52.3%, significantly boosting drug delivery.
The precise modulation of hydrophobic characteristics plays a critical role in controlling nanotube length and polydispersity.
PCC nanotubes show tumor-selective cytotoxicity with 20- to 50-fold greater potency against tumor cells than normal cells.
Nanotubes formed are of intermediate length (0.3–0.5 µm), providing advantages like prolonged circulation times over conventional liposomes.

Gao et al. (2025) studied this question.

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