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Phospholipid‐Drug Conjugates Self‐Organized into Well‐Defined Supramolecular Nanotubes for Efficient Drug Delivery

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Self-organizing phospholipid-drug conjugates exhibit high drug-loading efficiencies and tumor-selective cytotoxicity.

PCC nanotubes demonstrated a tumor-selective cytotoxicity that was 20- to 50-fold greater than that of normal cells.
Hydrophobic characteristics of PCC linkers significantly modulated π-stacking strength, impacting nanotube length from nano- to micro-scale.
PCC nanotubes achieved drug-loading efficiencies ranging from 43.9% to 52.3%, highlighting their potential in drug delivery applications.
Intermediate-length PCC nanotubes had longer circulation times compared to conventional liposomes, improving therapeutic efficacy.

Gao et al. (2025) studied this question.

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