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June 13, 2026Journal of Polymer Science

Hyaluronic Acid‐Decorated Hollow Nanocapsules for Enhanced Tumor‐Targeted Chemotherapy

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Authors

YQYiduo QianSMShina MaoZJZhizhan Ji

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Overview

Randomized trial examines enhanced drug delivery efficiency using hyaluronic acid nanocapsules in cancer therapy, indicating promising implications for treatment.

Key Points

  • The study aims to develop hyaluronic acid-decorated hollow nanocapsules for targeted drug delivery in breast cancer treatment.
  • Synthesis of hollow nanocapsules using Friedel–Crafts polymerization and esterification techniques.
  • Characterization of nanocapsules with a focus on morphology and drug entrapment efficiency.
  • In vitro studies comparing drug release rates and cytotoxic effects between targeted and non-targeted formulations.
  • Hyaluronic acid-decorated nanocapsules exhibited a drug entrapment efficiency of 45.83%.
  • Drug release was significantly lower at neutral pH, while acidic conditions accelerated release.
  • Compared to non-targeted formulations, the targeted nanocapsules showed higher cytotoxicity against MCF-7 cells.

Cite This Study

Qian et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf6d7faef96ed7f0587cehttps://doi.org/10.1002/pol.20250868
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