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February 21, 2026CureusOpen Access

Visual Performance Comparison Between Enhanced Monofocal and Extended Depth of Focus Intraocular Lenses: A Systematic Review and Meta-Analysis

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Authors

DBDanai BarpakiAristotle University of ThessalonikiDADiamantis AlmaliotisAristotle University of ThessalonikiSASofia Androudi

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Implication

A systematic review compares visual outcomes after cataract surgery using different intraocular lenses, suggesting further research is needed.

Key Points

  • This review aims to compare the visual outcomes of enhanced monofocal and extended depth of focus intraocular lenses after cataract surgery.
  • Systematic review and meta-analysis of studies comparing IOL types
  • Search conducted across MEDLINE, CENTRAL, clinicaltrials.gov, and ICTRP
  • Five studies including one randomized and four non-randomized designs
  • Outcomes measured include distance, intermediate, and near visual acuity along with glare perception
  • Risk of bias assessed with Cochrane RoB 2 and JBI tools
  • No significant difference in uncorrected or corrected distance visual acuity between IOL types
  • Mean differences for distance visual acuity approached zero with confidence intervals including zero
  • Heterogeneity observed in intermediate visual acuity results, preventing a quantitative synthesis
  • Subjective glare and halo perception varied across studies but were documented

Cite This Study

Barpaki et al. (2026) studied this question.

synapsesocial.com/papers/69994bdd873532290d01febchttps://doi.org/10.7759/cureus.103841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quality of vision clinical outcomes for a new fully-refractive extended depth of focus Intraocular Lens2024 · 50 citations
  2. 2Extended Depth-of-Field Intraocular Lenses: An Update2020 · 251 citations
  3. 3Through-Focus Vision Performance and Light Disturbances of 3 New Intraocular Lenses for Presbyopia Correction2018 · 116 citations
  4. 4Enhanced Depth‐of‐focus Intraocular Lenses: Latest Wavefront‐shaped Optics versus Diffractive Optics2022 · 16 citations
  5. 5RoB 2: a revised tool for assessing risk of bias in randomised trials2019 · 33,583 citations