This letter reports advances in studying ADP-ribosyl ubiquitination in biochemical modifications, suggesting new insights into cellular processes.
ADP-ribosyl ubiquitination is a unique form of crosstalk between post-translational modifications, where recently RNF114 has been identified as the first dedicated reader of this dual modification. New findings reveal that RNF114 extends the initial hybrid ADPr-Ub modification with K11-linked poly-Ub chains. This Letter highlights the recent advances made in methods and tools to study this hybrid signal and addresses some key questions that remain.
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Vries et al. (2026) studied this question.
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