What question did this study set out to answer?

The review aims to explore the roles and mechanisms of lncRNAs in glioma development and therapy.

Unraveling the Function of lncRNAs in Gliomas: Interaction With Signaling Pathways and Therapeutic Opportunities

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Authors

This review examines lncRNAs' roles in gliomas, highlighting therapeutic potentials in brain tumors.

The review aims to explore the roles and mechanisms of lncRNAs in glioma development and therapy.
Conducted a systematic review of literature from databases including PubMed, Scopus, and Web of Science.
Analyzed lncRNA biogenesis pathways and their interactions with oncogenic signaling.
Identified therapeutic strategies targeting lncRNA networks.
Highlighted the interplay between lncRNAs and key signaling pathways like PI3K/AKT and STAT3.
Discussed lncRNAs' roles as competitive endogenous RNAs (ceRNAs) and epigenetic regulators.
Identified significant gaps in understanding therapeutic effects of lncRNAs in clinical settings.

Doghish et al. (2026) studied this question.

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