What question did this study set out to answer?

This study aims to develop an in vitro model to understand the carcinogenic progression of HPV-positive oropharyngeal cancer.

February 21, 2026CancersOpen Access

In Vitro Model Characterizing Carcinogenic Progression of HPV-Positive Oropharyngeal Cancer

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In vitro model characterizes carcinogenic progression in HPV-positive oropharyngeal cancer, suggesting new diagnostic tools and biomarkers.

This study aims to develop an in vitro model to understand the carcinogenic progression of HPV-positive oropharyngeal cancer.
Developed a three-dimensional organotypic raft culture system.
Used HPV16-transfected human tonsil keratinocytes.
Monitored biochemical and structural changes in epithelial cells.
Generated stratified and differentiated epithelia that mimic in vivo conditions.
Enabled monitoring of key oncogenic and metabolic markers linked to HPV16.
Validated the model using expression profiles aligned with clinical datasets.

Tejeda et al. (2026) studied this question.

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In vitro model characterizes carcinogenic progression in HPV-positive oropharyngeal cancer, suggesting new diagnostic tools and biomarkers.