What question did this study set out to answer?

To evaluate how body mass index affects treatment response to neoadjuvant chemotherapy in breast cancer patients through meta-analysis.

February 21, 2026Tumori Journal

The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis

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To evaluate how body mass index affects treatment response to neoadjuvant chemotherapy in breast cancer patients through meta-analysis.
Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Cochrane Library
Eligibility criteria set for selecting studies
Data extraction and quality assessment performed using the Newcastle-Ottawa Scale
Statistical analyses conducted using R 4.4.1 and Stata 17
Fifteen studies with 15,235 patients were included
Overweight and obese patients had a significantly reduced pathological complete response (pCR) rate (OR: 0.79, p = 0.040) compared to those with normal or low BMI
Underweight individuals exhibited a higher pCR rate compared to those with normal BMI (OR: 1.56, p=0.015)
Overweight and obese cohorts showed a lower pCR rate compared to normal BMI individuals (OR: 0.83, p < 0.0001)

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Implication

This systematic review evaluates the influence of body mass index on chemotherapy response in breast cancer patients, suggesting implications for treatment decisions.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69994c6f873532290d020ed2 https://doi.org/10.1177/03008916251410090

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Implication

This systematic review evaluates the influence of body mass index on chemotherapy response in breast cancer patients, suggesting implications for treatment decisions.

The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis

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Discussion

Implication

Cite This Study

The impact of body mass index on the treatment response to neoadjuvant chemotherapy in patients with breast cancer: A systematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study

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