What question did this study set out to answer?

The aim was to assess the prevalence of obesity among high-risk breast cancer patients undergoing neoadjuvant chemotherapy and its impact on treatment tolerance.

March 12, 2026Open Access

Obesity and Tolerance to Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Cohort Study

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The aim was to assess the prevalence of obesity among high-risk breast cancer patients undergoing neoadjuvant chemotherapy and its impact on treatment tolerance.
Conducted a retrospective cohort analysis of stage I–III breast cancer patients assigned for neoadjuvant chemotherapy from January 2020 to December 2022.
Categorized patients by body mass index (BMI) and compared those with obesity to an age-matched non-obese group (1:1).
Evaluated chemotherapy-related toxicities including hospitalization, dose reduction, treatment delay, or discontinuation.
Performed multivariable logistic regression analyses adjusting for age, comorbidity burden, and carboplatin use.
31.2% of patients were overweight and 27.7% were obese.
Obese patients had a significantly higher incidence of peripheral neuropathy (63.7% vs. 36.3%, p < 0.001).
Obesity was associated with 1.83 times greater odds of global toxicity and 2.30 times greater odds of treatment discontinuation (both p < 0.05).

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Implication

Retrospective cohort study shows obesity increases chemotherapy toxicity in high-risk early-stage breast cancer, suggesting closer monitoring is needed.

Cite This Study

Machado et al. (2026) studied this question.

synapsesocial.com/papers/69b25b7196eeacc4fceca399 https://doi.org/10.3390/cancers18060889

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Implication

Retrospective cohort study shows obesity increases chemotherapy toxicity in high-risk early-stage breast cancer, suggesting closer monitoring is needed.

Obesity and Tolerance to Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Cohort Study

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Discussion

Implication

Cite This Study

Obesity and Tolerance to Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Cohort Study

Key Points

Discussion

Implication

Cite This Study

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