Retrospective cohort study evaluates long-term outcomes in childhood medulloblastoma survivors with posterior fossa syndrome, suggesting significant deficits.
Key Points
This study aims to evaluate the long-term impacts of posterior fossa syndrome on neurological and quality of life outcomes in survivors of childhood medulloblastoma.
Retrospective cohort design including childhood medulloblastoma survivors diagnosed from 1985 to 2012.
Participants assessed for neurological, neurocognitive, and social outcomes.
Statistical methods included Mann-Whitney U, χ2, Fisher exact tests, and multivariable linear regression.
158 participants assessed, with 37 having posterior fossa syndrome and 121 as controls.
Participants with posterior fossa syndrome showed significantly worse performance in focused attention and motor-processing speed.
8 times more likely to need assistance with daily activities compared to controls.