ID #912 Incidence and Clinical Characteristics of Posterior Fossa Syndrome in Children with brain tumours in Western Australia

Introduction Posterior Fossa Syndrome (PFS) is a collection of symptoms that occur following resection of a tumour from the posterior fossa. It most commonly occurs following resection of medulloblastoma. While PFS has been associated with various symptoms including ataxia, visual disturbance, hypotonia and behavioural changes, the characteristic symptom is cerebellar mutism. Incidence rate of PFS varies globally and differs among tumour type, with reported rates across all tumour subtypes between 8% and 27%. Medulloblastoma typically has the highest incidence rate, with some centres reporting rates as high as 35%. These numbers are reflective of global cohorts. There is scarcity of data from Australia-specific studies. Methods This is a retrospective cohort study conducted at Perth Children’s Hospital, assessing the incidence and clinical characteristics of PFS in children who underwent posterior fossa tumour resection over a 20-year period. Results The analysis of this retrospective cohort is ongoing and will be ready for presentation at the conference.