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February 21, 2026Antimicrobial Agents and ChemotherapyOpen Access

Epidemiology and genomics of azithromycin-resistant extensively drug-resistant Salmonella enterica serovar Typhimurium in Taiwan

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Authors

YHYu-Ping HongMinistry of Health and WelfareYLYing-Shu LiaoBCBo-Han Chen

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Implication

Analysis investigates azithromycin-resistant Salmonella in Taiwan, highlighting public health implications.

Key Points

  • To examine the genetic basis and evolution of azithromycin-resistant extensively drug-resistant Salmonella Typhimurium in Taiwan.
  • Analyzed 60 isolates of Salmonella enterica collected from human and animal sources.
  • Conducted whole-genome sequencing on multidrug-resistant and azithromycin-resistant isolates.
  • Identified resistance genes and plasmid structures among the isolates.
  • 36 of 45 multidrug-resistant isolates and all azithromycin-resistant isolates belonged to the HC50_13 subclone.
  • AziR-XDR isolates carried additional antimicrobial resistance genes on plasmids.
  • The HC50_13 subclone has increased notably since 2021, indicating local evolution of resistance.

Cite This Study

Hong et al. (2026) studied this question.

synapsesocial.com/papers/69994cdf873532290d021b76https://doi.org/10.1128/aac.01334-25
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