January 1, 2002Thrombosis and Haemostasis

Postpartum Bone Mineral Density in Women Treated for Thromboprophylaxis with Unfractionated Heparin or LMW Heparin

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Why the study?

Does dalteparin prevent bone mineral density loss compared to unfractionated heparin in pregnant women requiring thromboprophylaxis?

Population

Pregnant women with confirmed previous or current thromboembolism

Comparison

Low-molecular-weight heparin once daily… vs Unfractionated sodium heparin twice daily…

Design

RCT, randomised, open

Follow-up

up to 3 years after delivery

Authors

VPVille PettiläUniversity of Bern PLPekka LeinonenUniversity of California, San Francisco AMAntti MarkkolaUniversity of Helsinki

Discussion

Member takes

Implication

Clinicians may prefer dalteparin over unfractionated heparin for thromboprophylaxis in pregnancy; extends sparse RCT data on anticoagulant bone effects.

Structured PICO

Does dalteparin prevent bone mineral density loss compared to unfractionated heparin in pregnant women requiring thromboprophylaxis?

Population

Pregnant women with confirmed previous or current thromboembolism

Intervention

Low-molecular-weight heparin (dalteparin) once daily subcutaneously

Comparator

Unfractionated sodium heparin twice daily subcutaneously (and a healthy control group of delivered women)

Outcome

Bone mineral density (BMD) in the lumbosacral spine measured with DEXAsurrogate

Dalteparin preserves bone mineral density significantly better than unfractionated heparin when used for long-term thromboprophylaxis during and after pregnancy.

Cite This Study

Pettilä et al. (2002) studied this question.

synapsesocial.com/papers/699957b701330c633145d1bc https://doi.org/10.1055/s-0037-1612970

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Implication

Clinicians may prefer dalteparin over unfractionated heparin for thromboprophylaxis in pregnancy; extends sparse RCT data on anticoagulant bone effects.