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November 1, 1994International Journal of Gynecology & Obstetrics

Thromboembolic prophylaxis with low molecular weight heparin during pregnancy

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Why the study?

Does dalteparin prevent veno-pulmonary thromboembolic diseases in pregnant women at risk?

Population

24 women carrying 27 pregnancies with known risk of veno-pulmonary thromboembolic diseases in pregnancy

Design

Cohort

Follow-up

6 weeks postpartum

Authors

CRC. RasmussenUniversity of MichiganJWJ WadtUniversity of CopenhagenBJB. JacobsenRoche (Switzerland)

Discussion

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Implication

May support dalteparin prophylaxis in at-risk pregnancies; leaves open need for randomized confirmation of efficacy.

Structured PICO

Does dalteparin prevent veno-pulmonary thromboembolic diseases in pregnant women at risk?

P
Population
24 women carrying 27 pregnancies with known risk of veno-pulmonary thromboembolic diseases in pregnancy
I
Intervention
Dalteparin (low molecular weight heparin) 2500-10,000 anti-Xa U daily subcutaneously during part of pregnancy, targeted to a plasma concentration of 0.20-0.50 anti-Xa U/ml
O
Outcome
Clinical or paraclinical signs of thromboembolic diseases during pregnancy or 6 weeks postpartumhard clinical

Prophylactic dalteparin during pregnancy in women at risk for thromboembolic diseases was effective and safe, with no thromboembolic events or side effects observed.

Cite This Study

Rasmussen et al. (1994) studied this question.

synapsesocial.com/papers/6a83c0b16de9cd8ef3ee78behttps://doi.org/10.1016/0020-7292(94)90351-4

Topics

Pulmonary embolism
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of Low Molecular Weight Heparin in Pregnancy1992 · 182 citations
  2. 2Low Molecular Weight Heparin Novo (LHN-1) Does Not Cross the Placenta During the Second Trimester of Pregnancy1989 · 108 citations