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December 1, 1992International Journal of Gynecology & Obstetrics

Use of low molecular weight heparin for prophylaxis and treatment of thromboembolism in pregnancy

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Why the study?

Does low molecular weight heparin safely prevent and treat thromboembolism in pregnant women?

Population

6 pregnant women requiring treatment or prophylaxis of thromboembolism

Design

Case_series

Follow-up

Through pregnancy and puerperium

Authors

SGShmuel GillisTufts Medical CenterASA ShushanHadassah Medical CenterAEAmiram EldorUniversité Claude Bernard Lyon 1

Discussion

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Implication

May support LMWH consideration in pregnancy; leaves open need for prospective validation.

Structured PICO

Does low molecular weight heparin safely prevent and treat thromboembolism in pregnant women?

P
Population
6 pregnant women requiring treatment or prophylaxis of thromboembolism
I
Intervention
Low molecular weight heparin (LMWH) administered as a single daily injection for periods of 6 weeks to 6 months
O
Outcome
Thromboembolic and hemorrhagic complications during pregnancy or puerperiumhard clinical

Low molecular weight heparin appears to be a safe and effective alternative to standard heparin for thromboembolism prophylaxis and treatment during pregnancy.

Cite This Study

Gillis et al. (1992) studied this question.

synapsesocial.com/papers/6a6f84f6a528af2d65c3086chttps://doi.org/10.1016/0020-7292(92)90261-g
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacology and special clinical applications of low‐molecular‐weight heparins1988 · 19 citations
  2. 2Anticoagulants During Pregnancy1989 · 71 citations
  3. 3Thrombosis and Pregnancy in Congenital Deficiencies in AT III, Protein C or Protein S: Study of 78 Women1990 · 285 citations
  4. 4Heparin-Associated Thrombocytopenia Treatment with Low Molecular Weight Heparin1986 · 76 citations