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Genomic analysis reveals prevalence of resistance in Escherichia coli clinical isolates, suggesting improved detection methods for beta lactamases.
Introduction: Piperacillin-tazobactam (PTZ) resistance in Escherichia coli is mediated by TEM and OXA enzymes. However, such isolates may have borderline minimum inhibitory concentrations (MICs) between eight (susceptible) and 16 (susceptible but dose dependent) μg/mL. Routine susceptibility testing may fail to detect these mechanisms, leading to clinical failure. We aimed to determine the prevalence of these beta lactamases and the optimal detection method.
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Huang et al. (2026) studied this question.
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