What does this research mean for the field?

Remimazolam-induced paradoxical reactions are more prevalent in younger children and those receiving lower premedication doses, but do not adversely affect sedation or prognosis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to evaluate the incidence and impact of remimazolam-induced paradoxical reactions in children undergoing same-day bidirectional endoscopy.

February 22, 2026Minerva Anestesiologica1 citations

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Incidence and impact of remimazolam-induced paradoxical reactions in pediatric same-day bidirectional endoscopy: a randomized, controlled clinical trial

SZSiqi ZhouTongji Hospital YBYuan BiTongji Hospital SYS. F. YuShanghai Jiao Tong University

Key Points

The study aims to evaluate the incidence and impact of remimazolam-induced paradoxical reactions in children undergoing same-day bidirectional endoscopy.
Conducted a randomized, controlled clinical trial
Included children receiving different doses of premedication
Focused on measurement of paradoxical reactions during the procedure
Paradoxical reactions were more common in younger children
Lower premedication doses resulted in higher incidence of reactions
Paradoxical reactions did not negatively impact overall sedation or prognosis

Abstract

PR was more prevalent in the lower premedication dose group and younger children but did not adversely affect sedation or prognosis.

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Incidence and impact of remimazolam-induced paradoxical reactions in pediatric same-day bidirectional endoscopy: a randomized, controlled clinical trial

Key Points

Abstract

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